Chong Qin

Professor

Ocean University of China School of Medicine and Pharmacy; Marine Biomedical Research Institute of Qingdao

Short Biography

Dr. Qin Chong currently serves as the doctoral supervisor of School of Medicine and Pharmacy at Ocean University of China, Vice Dean of Marine Biomedical Research Institute of Qingdao. He has been extensively involved in the fields of medicinal chemistry, organic synthesis, and new drug research. His primary research interests include: (1) Discovery and development of Proteolysis Targeting Chimera (PROTAC)-based lead compounds; (2) Research on therapeutic drugs for castration-resistant prostate cancer; (3) Discovery and development of medicinal properties and improvement of druggability of marine natural bioactive substances. Dr. Qin has directed projects funded by the National High-Level Youth Talent Program, the National Key Research and Development Program of China for Young Scientists, and National Natural Science Foundation of China Youth Program. He has made significant achievements in the discovery of several targeted anti-cancer drugs, with related findings published in internationally influential journals such as the J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、J. Med. Chem.

Presentation Topic: The development and application of novel E3 ubiquitin ligase ligands
• Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy to expand the druggable proteome and overcome resistance mechanisms associated with conventional therapies.
• Rational optimization of E3 ubiquitin ligase ligands aid to enhance both target binding affinity and metabolic stability.
• The development of E3 binders with favorable physicochemical profiles contributes to broadening the scope of targeted protein degradation.
• Targeted protein degradation holds great promise in oncology, with evolving E3 ligands enabling more degraders to advance clinically.