Chang Hoon Ji

Research Associate Professor/Executive Director

Seoul National University, Cellular Degradation Biology Center/ AutotacBio, R&D Institute

Short Biography

I am a molecular and cellular biologist by training, working at the Cellular Degradation Biology Center in Seoul National University as a Research Associate Professor on the basic/translational science on autophagic Arg/N-degron pathway. Simultaneously, I am concurrently serving as the Executive Director of the R&D Institute at AutotacBio, Inc. for the drug development of heterobifunctional chimeric targeted protein degraders. My personal goal is to cover the entire width of the 'basic science - translational science - clinical development' spectrum for a comprehensive understanding and advancement of human health.

Presentation Topic: Beyond Oncology – TPD in Neurodegenerative Diseases using the Autophagy-Lysosome System via the AUTOphagy-TArgeting Chimera (AUTOTAC) platform

• Early proof-of-concept/design and pre-clinical/clinical development of a first-in-class tau aggregate degrader using the bimodal AUTOTAC platform

• Safety/tolerability and pharmacokinetic properties in humans (phase 1 clinical trial with healthy adults)

• Efficacy in higher-order mammalian models (phase 2 clinical field trial with demented canines)